BPN-15606

• Target :

  Others|||Gamma-secretase

• Related Pathways :

  Proteases/Proteasome|||Neuroscience|||Others|||Stem Cells

• Bioactivity :

  BPN-15606, an orally active ?-secretase modulator (GSM), significantly reduces A?42 and A?40 production in SHSY5Y neuroblastoma cells, demonstrating IC50 values of 7 nM and 17 nM, respectively. This compound exhibits favorable pharmacokinetic/pharmacodynamic (PK/PD) properties, such as bioavailability, half-life, and clearance. Importantly, BPN-15606 markedly decreases A?42 and A?40 levels in the central nervous system of both rats and mice[1].

• Smiles :

  COc1nc(ccc1-n1cnc(C)c1)-c1cc(C)c(N[C@@H](C)c2ccc(F)cc2)nn1

• Molecular Formula :

  C23H23FN6O

• Molecular Weight :

  418.47

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1914989-49-3