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BPN-15606

CAT: 0931-T10589L-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T10589L-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1914989-49-3
Target
Others, Gamma-secretase
Related Pathways
Proteases/Proteasome, Neuroscience, Others, Stem Cells
Bioactivity
BPN-15606, an orally active γ-secretase modulator (GSM), significantly reduces Aβ42 and Aβ40 production in SHSY5Y neuroblastoma cells, demonstrating IC50 values of 7 nM and 17 nM, respectively. This compound exhibits favorable pharmacokinetic/pharmacodynamic (PK/PD) properties, such as bioavailability, half-life, and clearance. Importantly, BPN-15606 markedly decreases Aβ42 and Aβ40 levels in the central nervous system of both rats and mice[1].
Smiles
COc1nc(ccc1-n1cnc(C)c1)-c1cc(C)c(N[C@@H](C)c2ccc(F)cc2)nn1
Molecular Formula
C23H23FN6O
Molecular Weight
418.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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Alternative Products

CatalogName
BA8589-1BPN-15606
A18681-100BPN-15606 100mg
A18681-50BPN-15606 50mg
MBS5806744BPN-15606 besylate
HY-117482ABPN-15606 (besylate)
A18681-10BPN-15606 10mg
A18681-25BPN-15606 25mg
A18681-5BPN-15606 5mg
A18681-10mM-DBPN-15606 10mM * 1mL in DMSO
GTR19229808-01BPN-15606 besylate (1914989-49-3 free base)

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