BI-4020

• Target:

  EGFR

• Related Pathways:

  JAK/STAT signaling|||Tyrosine Kinase/Adaptors|||Angiogenesis

• Purity:

  >99.99%

• Bioactivity:

  BI-4020 is a fourth-generation, orally active, and non-covalent inhibitor of EGFR tyrosine kinase. It exhibits activity against the triple mutant EGFR del19 T790M C797S variant (IC50=0.2 nM in BaF3 cell lines), the double mutant EGFR del19 T790M and primary mutant EGFR del19 (IC50=1 nM), and EGFR wt (IC50=190 nM) . BI-4020 also shows high kinome selectivity and good DMPK properties.

• Smiles:

  C[C@@H]1CCCOc2c(cnn2C)-c2cc(cc(C)n2)C(=O)\N=C2/Nc3ccc(CN4CCN(C)CC4)cc3N2C1

• Molecular Formula:

  C30H38N8O2

• Molecular Weight:

  542.68

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2664214-60-0