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AM103

CAT: 0931-T10314-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T10314-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1147872-22-7
Target
FLAP
Related Pathways
Immunology/Inflammation
Purity
0.9975
Bioactivity
AM103 is an effective and selective inhibitor of FLAP (IC50 = 4.2 nM) .
Smiles
[Na+].COc1ccc(cn1)-c1ccc(Cn2c(CC(C)(C)C([O-])=O)c(SC(C)(C)C)c3cc(OCc4ccccn4)ccc23)cc1
Molecular Formula
C36H38N3NaO4S
Molecular Weight
631.76
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

AM-103

AM103 is a novel inhibitor of 5-lipoxygenase-activiting protein (FLAP) that has demonstrated potential to treat asthma and cardiovascular disease by preventing the synthesis of LT, which triggers inflammation. It is being developed by Amira.

CAS Number1147872-22-7
PubChem CID59248882
IUPAC Namesodium 3-[3-tert-butylsulfanyl-1-[[4-(6-methoxy-3-pyridinyl)phenyl]methyl]-5-(pyridin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoate
Molecular FormulaC36H38N3NaO4S
Molecular Weight631.8
Topological Polar Surface Area115
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count12
Heavy Atom Count45
Formal Charge0
Complexity926
SMILES
CC(C)(C)SC1=C(N(C2=C1C=C(C=C2)OCC3=CC=CC=N3)CC4=CC=C(C=C4)C5=CN=C(C=C5)OC)CC(C)(C)C(=O)[O-].[Na+]
InChI
InChI=1S/C36H39N3O4S.Na/c1-35(2,3)44-33-29-19-28(43-23-27-9-7-8-18-37-27)15-16-30(29)39(31(33)20-36(4,5)34(40)41)22-24-10-12-25(13-11-24)26-14-17-32(42-6)38-21-26;/h7-19,21H,20,22-23H2,1-6H3,(H,40,41);/q;+1/p-1
InChIKey
NJJMCCVPHCNMPB-UHFFFAOYSA-M
Chemical Structure
2D Structure
2D structure of AM-103
CAS: 1147872-22-7
CID: 59248882
Formula: C36H38N3NaO4S
MW: 631.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight631.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count12
Exact Mass631.24807216
Monoisotopic Mass631.24807216
Topological Polar Surface Area115 Ų
Heavy Atom Count45
Formal Charge0
Complexity926
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS5766046AM103
HY-14162AM103 (free acid)

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