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AM103

CAT: 0804-HY-14163-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14163-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AM 103 is a potent and selective FLAP inhibitor, with an IC50 value of 4.2 nM.
CAS Number
1147872-22-7
UNSPSC
12352005
Target
FLAP
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/AM_103.html
Purity
99.26
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C(O[Na])C(C)(C)CC(N1CC2=CC=C(C3=CC=C(OC)N=C3)C=C2)=C(SC(C)(C)C)C4=C1C=CC(OCC5=NC=CC=C5)=C4
Molecular Formula
C36H38N3NaO4S
Molecular Weight
631.76
References & Citations
[1]Hutchinson JH, et al. 5-lipoxygenase-activating protein inhibitors: development of 3-[3-tert-butylsulfanyl-1-[4- (6-methoxy-pyridin-3-yl) -benzyl]-5- (pyridin-2-ylmethoxy) -1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103) . J Med Chem. 2009 Oct 8;52 (19) :5803-15.|[2]Lorrain DS, et al. Pharmacological characterization of 3-[3-tert-butylsulfanyl-1-[4- (6-methoxy-pyridin-3-yl) -benzyl]-5- (pyridin-2-ylmethoxy) -1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103), a novel selective 5-lipoxygenase-activating protein inhibitor that reduces acute and chronic inflammation. J Pharmacol Exp Ther. 2009 Dec;331 (3) :1042-50.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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CatalogName
MBS5766046AM103

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