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Luteolin

CAT: 0931-T1027-04Size: 1 mL - 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0931-T1027-04Size:1 mL - 10 mM (in DMSO)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
491-70-3
Target
Autophagy, Apoptosis, PDE, Endogenous Metabolite, Nrf2
Related Pathways
Apoptosis, Autophagy, Immunology/Inflammation, Metabolism
Purity
0.9971
Bioactivity
Luteolin (Luteolol) belongs to the flavonoid group of natural products and is a Nrf2 inhibitor, PDE inhibitor. Luteolin has a wide range of biological activities including antitumor, antioxidant, anti-inflammatory, antimicrobial, antiviral, antiallergic, and procoagulant.
Smiles
O=C1C=2C(OC(=C1)C3=CC(O)=C(O)C=C3)=CC(O)=CC2O
Molecular Formula
C15H10O6
Molecular Weight
286.24
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Luteolin

Luteolin is a tetrahydroxyflavone in which the four hydroxy groups are located at positions 3', 4', 5 and 7. It is thought to play an important role in the human body as an antioxidant, a free radical scavenger, an anti-inflammatory agent and an immune system modulator as well as being active against several cancers. It has a role as an antineoplastic agent, an angiogenesis inhibitor, a radical scavenger, an immunomodulator, a vascular endothelial growth factor receptor antagonist, an anti-inflammatory agent, an apoptosis inducer, an EC 2.3.1.85 (fatty acid synthase) inhibitor, a nephroprotective agent, a plant metabolite and a c-Jun N-terminal kinase inhibitor. It is a 3'-hydroxyflavonoid and a tetrahydroxyflavone. It is a conjugate acid of a luteolin-7-olate.

CAS Number491-70-3
PubChem CID5280445
IUPAC Name2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one
Molecular FormulaC15H10O6
Molecular Weight286.24
XLogP1.4
Topological Polar Surface Area107
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count1
Heavy Atom Count21
Formal Charge0
Complexity447
SMILES
C1=CC(=C(C=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O)O
InChI
InChI=1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H
InChIKey
IQPNAANSBPBGFQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Luteolin
CAS: 491-70-3
CID: 5280445
Formula: C15H10O6
MW: 286.24
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight286.24
XLogP31.4
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count1
Exact Mass286.04773803
Monoisotopic Mass286.04773803
Topological Polar Surface Area107 Ų
Heavy Atom Count21
Formal Charge0
Complexity447
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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