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Aclacinomycin A hydrochloride

CAT: 0931-T10238Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T10238Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
75443-99-1
Target
DNA/RNA Synthesis, ROS, DNA, Proteasome, Topoisomerase, Antibiotic
Related Pathways
Cell Cycle/Checkpoint, Microbiology/Virology, Immunology/Inflammation, Proteases/Proteasome, DNA Damage/DNA Repair, Ubiquitination
Bioactivity
Aclacinomycin A hydrochloride (Aclarubicin HCl) is an anthracycline antibiotic and inhibitor of topoisomerase I/II, interfering with DNA transcription and replication, inhibiting tumour invasion and angiogenesis, generating reactive oxygen species (ROS), and inhibiting the catalytic centre of the 20S proteasome. It is indicated for the treatment of relapsed leukaemia and advanced malignant lymphoma.
Smiles
C(OC)(=O)[C@@H]1C2=C([C@@H](O[C@H]3C[C@H](N(C)C)[C@H](O[C@H]4C[C@H](O)[C@H](O[C@@H]5O[C@@H](C)C(=O)CC5)[C@H](C)O4)[C@H](C)O3)C[C@@]1(CC)O)C(O)=C6C(=C2)C(=O)C=7C(C6=O)=C(O)C=CC7.Cl
Molecular Formula
C42H54ClNO15
Molecular Weight
848.33
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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