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Irinotecan Hydrochloride

CAT: 0931-T0486L-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T0486L-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
100286-90-6
Target
Autophagy, Topoisomerase
Related Pathways
Autophagy, DNA Damage/DNA Repair
Purity
0.9994
Bioactivity
Irinotecan Hydrochloride (CPT-11 hydrochloride) is the hydrochloride salt of a semisynthetic derivative of camptothecin. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting enzyme. One thousand-fold more potent than its parent compound irinotecan, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death. Because ongoing DNA synthesis is necessary for irinotecan to exert its cytotoxic effects, it is classified as an S-phase-specific agent.
Smiles
Cl.CCc1c2Cn3c(cc4c(COC(=O)[C@]4(O)CC)c3=O)-c2nc2ccc(OC(=O)N3CCC(CC3)N3CCCCC3)cc12
Molecular Formula
C33H39ClN4O6
Molecular Weight
623.14
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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