Irinotecan

• Target:

  Topoisomerase|||Autophagy

• Related Pathways:

  Autophagy|||DNA Damage/DNA Repair

• Purity:

  >99.99%

• Bioactivity:

  Irinotecan (CPT-11), a derivative of camptothecin, is an inhibitor of DNA topoisomerase I (Topo I) . Irinotecan has antitumor activity by preventing DNA strand reattachment through binding to the Topo I complex, resulting in double-stranded DNA breaks and cell death.

• Smiles:

  CCc1c2Cn3c(cc4c(COC(=O)[C@]4(O)CC)c3=O)-c2nc2ccc(OC(=O)N3CCC(CC3)N3CCCCC3)cc12

• Molecular Formula:

  C33H38N4O6

• Molecular Weight:

  586.68

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  97682-44-5