ABL (T315I) Protein, Active

• Description:

  ABL (T315I) Protein, Active_x000D_ Catalog number: B2019394_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: .02 mL_x000D_ Molecular Weight or Concentration: 280kDa (MAP2a and MAP2b), 70kDa (MAP2c)_x000D_ Supplied as: Solution_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: −20°C_x000D_ Keywords: ABL (T315I) Protein, Active_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Hughes TP, Mauro MJ, Cortes JE, Minami H, Rea D, DeAngelo DJ, Breccia M, Goh YT, Talpaz M, Hochhaus A, le Coutre P, Ottmann O, Heinrich MC, Steegmann JL, Deininger MWN, Janssen JJWM, Mahon FX, Minami Y, Yeung D, Ross DM, Tallman MS, Park JH, Druker BJ, Hynds D, Duan Y, Meille C, Hourcade-Potelleret F, Vanasse KG, Lang F, Kim DW. Asciminib in Chronic Myeloid Leukemia after ABL Kinase Inhibitor Failure N Engl J Med. 2019 Dec 12;381(24):2315-2326._x000D_ 2: Senapati J, Sasaki K, Issa GC, Lipton JH, Radich JP, Jabbour E, Kantarjian HM. Management of chronic myeloid leukemia in 2023 - common ground and common sense Blood Cancer J. 2023 Apr 24;13(1):58._x000D_ 3: Cortes JE, Kim DW, Pinilla-Ibarz J, le Coutre P, Paquette R, Chuah C, Nicolini FE, Apperley JF, Khoury HJ, Talpaz M, DiPersio J, DeAngelo DJ, Abruzzese E, Rea D, Baccarani M, Müller MC, Gambacorti-Passerini C, Wong S, Lustgarten S, Rivera VM, Clackson T, Turner CD, Haluska FG, Guilhot F, Deininger MW, Hochhaus A, Hughes T, Goldman JM, Shah NP, Kantarjian H; PACE Investigators. A phase 2 trial of ponatinib in Philadelphia chromosome-positive leukemias N Engl J Med. 2013 Nov 7;369(19):1783-96._x000D_ 4: Réa D, Hughes TP. Development of asciminib, a novel allosteric inhibitor of BCR-ABL1 Crit Rev Oncol Hematol. 2022 Mar;171:103580._x000D_ 5: Kawakami S, Tsuma-Kaneko M, Sawanobori M, Uno T, Nakamura Y, Matsuzawa H, Suzuki R, Onizuka M, Yahata T, Naka K, Ando K, Kawada H. Pterostilbene downregulates BCR/ABL and induces apoptosis of T315I-mutated BCR/ABL-positive leukemic cells Sci Rep. 2022 Jan 13;12(1):704._x000D_ 6: Elsir Khair H, Ahmed Mohamed B, Yousef Nour B, Ali Waggiallah H. Prevalence of BCR-ABL T315I Mutation in Different Chronic Myeloid Leukemia patients Categories Pak J Biol Sci. 2022 Jan;25(2):175-181._x000D_ 7: Jiang Q, Li Z, Qin Y, Li W, Xu N, Liu B, Zhang Y, Meng L, Zhu H, Du X, Chen S, Liang Y, Hu Y, Liu X, Song Y, Men L, Chen Z, Niu Q, Wang H, Lu M, Yang D, Zhai Y, Huang X. Olverembatinib (HQP1351), a well-tolerated and effective tyrosine kinase inhibitor for patients with T315I-mutated chronic myeloid leukemia: results of an open-label, multicenter phase 1/2 trial J Hematol Oncol. 2022 Aug 18;15(1):113._x000D_ 8: Deeks ED. Asciminib: First Approval Drugs. 2022 Feb;82(2):219-226._x000D_ 9: Mauro MJ, Hughes TP, Kim DW, Rea D, Cortes JE, Hochhaus A, Sasaki K, Breccia M, Talpaz M, Ottmann O, Minami H, Goh YT, DeAngelo DJ, Heinrich MC, Gómez-García de Soria V, le Coutre P, Mahon FX, Janssen JJWM, Deininger M, Shanmuganathan N, Geyer MB, Cacciatore S, Polydoros F, Agrawal N, Hoch M, Lang F. Asciminib monotherapy in patients with CML-CP without BCR::ABL1 T315I mutations treated with at least two prior TKIs: 4-year phase 1 safety and efficacy results Leukemia. 2023 May;37(5):1048-1059._x000D_ 10: Kantarjian HM, Jabbour E, Deininger M, Abruzzese E, Apperley J, Cortes J, Chuah C, DeAngelo DJ, DiPersio J, Hochhaus A, Lipton J, Nicolini FE, Pinilla-Ibarz J, Rea D, Rosti G, Rousselot P, Shah NP, Talpaz M, Srivastava S, Ren X, Mauro M. Ponatinib after failure of second-generation tyrosine kinase inhibitor in resistant chronic-phase chronic myeloid leukemia Am J Hematol. 2022 Nov;97(11):1419-1426. _x000D_ _x000D_ Products Related to ABL (T315I) Protein, Active can be found at Proteins

• Short Description:

  Catalog Number: B2019394 (.02 mL)

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height:

  0.5

• Height :

  0.5