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Lascufloxacin

CAT: 0804-HY-16745-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16745-01Size:1 mg
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Description
Lascufloxacin (KRP-AM1977X) is a potent and orally active fluoroquinolone antibacterial agent. Lascufloxacin potently inhibits infections caused by various pathogens, including quinolone-resistant strains. Lascufloxacin has the potential for various infectious diseases treatment, including lower respiratory tract infections[1][2].
CAS Number
848416-07-9
Product Name Alternative
KRP-AM1977
UNSPSC
12352005
Target
Antibiotic; Bacterial; Beta-lactamase
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/lascufloxacin.html
Purity
98.04
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(C1=CN(CCF)C2=C(C=C(F)C(N3C[C@H](CNC4CC4)[C@H](F)C3)=C2OC)C1=O)O
Molecular Formula
C21H24F3N3O4
Molecular Weight
439.43
References & Citations
[1]Kishii R, et al. In Vitro Activities and Spectrum of the Novel Fluoroquinolone Lascufloxacin (KRP-AM1977) . Antimicrob Agents Chemother. 2017 May 24;61 (6) . pii: e00120-17.|[2]Furuie H, et al. Intrapulmonary Pharmacokinetics of Lascufloxacin in Healthy Adult Volunteers. Antimicrob Agents Chemother. 2018 Mar 27;62 (4) . pii: e02169-17.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Quinolone

Chemical Information

Lascufloxacin

Lascufloxacin is a small molecule drug. The usage of the INN stem '-oxacin' in the name indicates that Lascufloxacin is a nalidixic acid derivative antibacterial. Lascufloxacin has a monoisotopic molecular weight of 439.17 Da.

CAS Number848416-07-9
PubChem CID71528768
IUPAC Name7-[(3S,4S)-3-[(cyclopropylamino)methyl]-4-fluoropyrrolidin-1-yl]-6-fluoro-1-(2-fluoroethyl)-8-methoxy-4-oxoquinoline-3-carboxylic acid
Molecular FormulaC21H24F3N3O4
Molecular Weight439.4
XLogP0.8
Topological Polar Surface Area82.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count8
Heavy Atom Count31
Formal Charge0
Complexity735
SMILES
COC1=C2C(=CC(=C1N3C[C@@H]([C@@H](C3)F)CNC4CC4)F)C(=O)C(=CN2CCF)C(=O)O
InChI
InChI=1S/C21H24F3N3O4/c1-31-20-17-13(19(28)14(21(29)30)9-26(17)5-4-22)6-15(23)18(20)27-8-11(16(24)10-27)7-25-12-2-3-12/h6,9,11-12,16,25H,2-5,7-8,10H2,1H3,(H,29,30)/t11-,16+/m0/s1
InChIKey
ZFIOCUITTUUVPV-MEDUHNTESA-N
Chemical Structure
2D Structure
2D structure of Lascufloxacin
CAS: 848416-07-9
CID: 71528768
Formula: C21H24F3N3O4
MW: 439.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight439.4
XLogP30.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count8
Exact Mass439.17189074
Monoisotopic Mass439.17189074
Topological Polar Surface Area82.1 Ų
Heavy Atom Count31
Formal Charge0
Complexity735
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
YIB41607-01Lascufloxacin
MBS5775357Lascufloxacin HCl

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