Recombinant TLR4 Antibody

CAT: 0013-GTR18575155Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0013-GTR18575155Size:100 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

This MAb reacts with human Toll-like receptor 4 (TLR4) . It is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.

UniProt

O00206

Reactivity

Human

Immunogen

Recombinant full-length human TLR4 protein was used as the immunogen for the recombinant TLR4 antibody.

Clonality

Recombinant

Clone

TLR4/3895R

Conjugation

Unconjugated

Field of Research

Immunology & Inflammation

Purification

Protein A affinity chromatography

Dilution

ELISA: order Ab without BSA for coating

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Applications Notes

Optimal dilution of the recombinant TLR4 antibody should be determined by the researcher.

Tested Applications

ELISA

Host or Source

Rabbit

Preservative

1 mg/ml in 1X PBS; rAlbumin free, sodium azide free

Isotype

Rabbit IgG

UniProtKB · O00206

Toll-like receptor 4

TLR4_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: O00206
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: TLR4
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: Precursor
Secondary accessions: A8K1Y8, A9XLP9, A9XLQ0, A9XLQ1, B4E194, D1CS52, D1CS53, Q5VZI8, Q5VZI9, Q9UK78, Q9UM57

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Disease

Age-related macular degeneration

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneCell projectionEndosomeMembrane

PTM

Disulfide bondGlycoproteinUbl conjugation

Biological process

ImmunityInflammatory responseInnate immunity

Domain

Leucine-rich repeatRepeatSignalTransmembraneTransmembrane helix

Ligand

NAD

Molecular function

Receptor

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