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Recombinant TLR4 Antibody

CAT: 0800-V8385-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V8385-100UGSize:100 µg
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Description
This MAb reacts with human Toll-like receptor 4 (TLR4) . It is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.
CAS Number
9000-83-3
Specifications
ELISA: order Ab without BSA for coating
UniProt
O00206
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant full-length human TLR4 protein was used as the immunogen for the recombinant TLR4 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG
Clone
TLR4/3895R
Type
Recombinant
Applications
ELISA
Purity
Protein A affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the recombinant TLR4 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This recombinant TLR4 antibody is available for research use only.
Storage Conditions
Store the recombinant TLR4 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the recombinant TLR4 antibody should be determined by the researcher.
Location
Cell surface
Image Legend
SDS-PAGE analysis of purified, BSA-free TLR4 antibody (clone TLR4/3895R) as confirmation of integrity and purity.

UniProtKB · O00206

Toll-like receptor 4

TLR4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O00206
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TLR4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A8K1Y8, A9XLP9, A9XLQ0, A9XLQ1, B4E194, D1CS52, D1CS53, Q5VZI8, Q5VZI9, Q9UK78, Q9UM57
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Disease

Age-related macular degeneration

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneCell projectionEndosomeMembrane

PTM

Disulfide bondGlycoproteinUbl conjugation

Biological process

ImmunityInflammatory responseInnate immunity

Domain

Leucine-rich repeatRepeatSignalTransmembraneTransmembrane helix

Ligand

NAD

Molecular function

Receptor
Product Datasheet
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