Recombinant CD74 / CL Antibody

CAT: 0013-GTR18575083Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0013-GTR18575083Size:100 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

It recognizes a protein of ~35kDa, identified as CD74 (Workshop IV) . CD74 is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74 stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. Anti-CD74 has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+) .

UniProt

P04233

Reactivity

Human

Immunogen

SU-DHL-4 lymphoma cells were used as the immunogen for this recombinant CD74 antibody.

Clonality

Recombinant

Clone

CLIP/3127R

Conjugation

Unconjugated

Field of Research

Immunology & Inflammation; Cell Biology

Purification

Protein A affinity chromatography

Dilution

Flow cytometry: 1-2ug/10^6 cells in 0.1ml, Western blot: 1-2ug/ml, Immunohistochemistry (FFPE) : 1-2ug/ml

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Applications Notes

Optimal dilution of the recombinant CD74 antibody should be determined by the researcher.

Tested Applications

FACS, IHC-P, WB

Host or Source

Rabbit

Preservative

1 mg/ml in 1X PBS; rAlbumin free, sodium azide free

Isotype

Rabbit IgG, kappa

UniProtKB · P04233

HLA class II histocompatibility antigen gamma chain

HG2A_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P04233
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: CD74
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: A8K7R1, B4DNE8, D3DQG3, D3DQG4, Q14597, Q29832, Q5U0J8, Q8SNA0, Q8WLP6

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

Adaptive immunityImmunity

Coding sequence diversity

Alternative initiationAlternative splicing

Cellular component

Cell membraneEndoplasmic reticulumEndosomeGolgi apparatusLysosomeMembraneSecreted

Molecular function

Chaperone

PTM

Disulfide bondGlycoproteinPhosphoproteinProteoglycan

Domain

Signal-anchorTransmembraneTransmembrane helix

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