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Cyclin B2 Antibody / CCNB2

CAT: 0013-GTR18575044Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18575044Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
In eukaryotic cells, mitosis is initiated following the activation of a protein kinase known variously as maturation-promoting factor, M phase specific histone kinase or M-phase kinase. This protein kinase is composed of a catalytic subunit (Cdc2), a regulatory subunit (cyclin B) and a low molecular weight subunit (p13-Suc1) . The Cdc/cyclin enzyme is subject to multiple levels of control, of which the regulation of the catalytic subunit by tyrosine phosphorylation is the best understood. Tyrosine phosphorylation inhibits the Cdc2/ cyclin B enzyme, and tyrosine dephosphorylation, occurring at the onset of mitosis, directly activates the pre-MPF complex. Evidence has established that B type cyclins not only act on M phase regulatory subunits of the Cdc2 protein kinase, but also activate the Cdc25A and Cdc25B endogenous tyrosine phosphatase, of which Cdc2 is the physiological substrate. The two B type cyclins, cyclin B1 and cyclin B2, have been shown to have distinct tissue distributions.
UniProt
O95067
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant full-length Xenopus laevis Cyclin B2 protein was used as the immunogen for this Cyclin B2 antibody.
Clonality
Monoclonal
Clone
X29.2
Conjugation
Unconjugated
Purification
Protein G affinity chromatography
Dilution
ELISA (order BSA-free format for coating)
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the Cyclin B2 antibody should be determined by the researcher.
Tested Applications
ELISA
Host or Source
Mouse
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Mouse IgG1, kappa

UniProtKB · O95067

G2/mitotic-specific cyclin-B2

CCNB2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O95067
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CCNB2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B3KM93, Q6FI99
Protein keywords

Biological process

Cell cycleCell divisionMitosis

Molecular function

Cyclin

PTM

Phosphoprotein

Technical term

Proteomics identificationReference proteome

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