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Cyclin E1 Antibody / CCNE1

CAT: 0013-GTR18575041Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18575041Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cyclin E belongs to the highly conserved cyclin family, whose members exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclins function as regulators of CDK kinases. Cyclin E forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. Cyclin E accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Cyclin E overexpression has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis.
UniProt
P24864
Reactivity
Human
Immunogen
A recombinant human partial protein (amino acids 10-176) was used as the immunogen for this Cyclin E1 antibody.
Clonality
Monoclonal
Clone
CCNE1/2587
Conjugation
Unconjugated
Field of Research
Cancer Biology
Purification
Protein G affinity chromatography
Dilution
ELISA (order BSA-free format for coating)
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the Cyclin E1 antibody should be determined by the researcher.
Tested Applications
ELISA
Host or Source
Mouse
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Mouse IgG

UniProtKB · P24864

G1/S-specific cyclin-E1

CCNE1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P24864
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CCNE1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A8K684, Q14091, Q8NFG1, Q92501, Q9UD21
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Cell cycleCell division

Molecular function

Cyclin

Cellular component

Nucleus

PTM

PhosphoproteinUbl conjugation

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