RegisterLogin

SGK1, Active

CAT: 0026-7748-5Size: 5 µgDry Ice: YesHazardous: No
CAT#:0026-7748-5Size:5 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
SGK1 is a member of the serum- and glucocorticoid-induced protein kinase that is activated in vitro by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and in vivo in response to signals that activate phosphatidylinositol (PI) 3-kinase (1). SGK1, mRNA is expressed in all tissues and the levels of SGK1 mRNA is increased by stimulation with serum or dexamethasone. SGK1 promotes cell survival by phosphorylating and inactivating FKHRL1. SGK and Akt display differences with respect to the efficacy with which they phosphorylate the three regulatory sites on FKHRL1. While both kinases can phosphorylate Thr-32, SGK1 displays a marked preference for Ser-315 whereas Akt favors Ser-253. These findings suggest that SGK1 and Akt may coordinately regulate the function of FKHRL1 by phosphorylating this transcription factor at distinct sites. Like PKB, SGK1 preferentially phosphorylate Ser and Thr residues that lie in Arg-Xaa-Arg-Xaa-Xaa-Ser/Thr motifs. SGK1 gene has recently been identified as an important aldosterone-induced protein kinase that mediates trafficking of the renal epithelial Na(+) channel (ENaC) to the cell membrane. Thus, SGK1 is an appealing candidate for blood pressure regulation and possibly essential hypertension (3).
Shipping Conditions
dry ice
Storage Conditions
-80°C
Shelf Life
12 months

Related Products

CatalogName
7749-5SGK2, Active
A1693-100Anti-SGK1 Antibody
7718-5PKCzeta, Active
7740-5CAMK4, Active
7758-5TrkB, Active
7703-100Akt3, Active
7707-5PAK4, Active
7724-5FGR, Active
7737-5MAPKAPK2, Active
7731-5PKCeta, Active

Alternative Products

CatalogName
MBS515659-01SGK1, Active
B2021449SGK1 Protein, Active
3200-KS-010Recombinant Human Active SGK1 (60-end) CF
220262SGK1, Active, Recombinant, Human (Serum and Glucocorticoid-regulated Protein Kinase) discontinued
S1010-85ESGK1, active, Recombinant, Human (Serum and Glucocorticoid-regulated Protein Kinase 1)
MBS659282-01SGK, active, delta 1-60, S422D (SGK1, Serum and Glucocorticoid-regulated Protein Kinase)
MBS636873-01SGK, active, truncated NT 60aa, Recombinant, Human (SGK1, Serum and Glucocorticoid-regulated Protein Kinase)
S1010-81SGK, active, delta 1-60, S422D, Human (SGK1, Serum and Glucocorticoid-regulated Protein Kinase)
S1010-81ESGK, active, truncated NT 60aa, Recombinant, Human, GST-Tag (SGK1, Serum and Glucocorticoid-regulated Protein Kinase) discontinued. see S1010-85E
576173-01SGK1

Popular Products