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MCU-i11

CAT: 0804-HY-W194810-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W194810-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MCU-i11 is a negative regulator of the mitochondrial calcium uniporter (MCU) complex. MCU-i11 can reduce mitochondrial Ca2+ uptake. MCU-i11 impairs muscle cell growth. MCU-i11 can be used to study breast cancer, cervical cancer and neurological diseases[1][2][3].
CAS Number
902903-59-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Calcium Channel; Mitochondrial Metabolism
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mcu-i11.html
Purity
98.42
Solubility
DMSO : 87.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NC1=CC=C(OCC)C=C1)CN2C(N(CC3=CC=CC=C3)C(C4=C2SC5=C4CCN(C(C)=O)C5)=O)=O
Molecular Formula
C28H28N4O5S
Molecular Weight
532.61
Precautions
H302, H315, H319, H335
References & Citations
[1]Di Marco G, et al. A High-Throughput Screening Identifies MICU1 Targeting Compounds. Cell Rep. 2020 Feb 18;30 (7) :2321-2331.e6.|[2]Marmolejo-Garza A, et al. Negative modulation of mitochondrial calcium uniporter complex protects neurons against ferroptosis. Cell Death Dis. 2023 Nov 25;14 (11) :772.|[3]Serrat R, et al. Astroglial ER-mitochondria calcium transfer mediates endocannabinoid-dependent synaptic integration. Cell Rep. 2021 Dec 21;37 (12) :110133.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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