MCUF-651

• Description :

  MCUF-651 is an orally active guanylyl cyclase A receptor (GC-A) positive allosteric modulator (PAM) (KD: 397 nM) . MCUF-651 binds to GC-A and selectively enhances the binding of atrial natriuretic peptide (ANP) to GC-A. MCUF-651 enhances ANP-mediated cGMP generation in human cardiac, renal, and fat cells. MCUF-651 inhibits cardiomyocyte hypertrophy[1].

• UNSPSC :

  12352005

• Target :

  Guanylate Cyclase

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/mcuf-651.html

• Purity :

  99.85

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=C(C1CN(CCC1)CCN(C)C)NC2=NC3=C(S2)C=C(F)C=C3F

• Molecular Formula :

  C17H22F2N4OS

• Molecular Weight :

  368.44

• References & Citations :

  [1]Sangaralingham SJ, et al. Discovery of small molecule guanylyl cyclase A receptor positive allosteric modulators. Proc Natl Acad Sci U S A. 2021 Dec 28;118 (52) :e2109386118.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2747162-85-0]