MCUF-651

• Description:

  MCUF-651 is an orally active guanylyl cyclase A receptor (GC-A) positive allosteric modulator (PAM) (KD: 397 nM) . MCUF-651 binds to GC-A and selectively enhances the binding of atrial natriuretic peptide (ANP) to GC-A. MCUF-651 enhances ANP-mediated cGMP generation in human cardiac, renal, and fat cells. MCUF-651 inhibits cardiomyocyte hypertrophy[1].

• UNSPSC:

  12352005

• Target:

  Guanylate Cyclase

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/mcuf-651.html

• Purity:

  99.85

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C (C1CN (CCC1) CCN (C) C) NC2=NC3=C (S2) C=C (F) C=C3F

• Molecular Formula:

  C17H22F2N4OS

• Molecular Weight:

  368.44

• References & Citations:

  [1]Sangaralingham SJ, et al. Discovery of small molecule guanylyl cyclase A receptor positive allosteric modulators. Proc Natl Acad Sci U S A. 2021 Dec 28;118 (52) :e2109386118.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2747162-85-0