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Bimatoprost grenod

CAT: 0804-HY-139419-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-139419-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bimatoprost grenod (NCX 470) is a second-generation nitric oxide (NO) -donating prostaglandin analogue. Bimatoprost grenod effectively lowers intraocular pressure (IOP) in animal models of ocular hypertension and glaucoma by activating bimatoprost-mediated uveoscleral outflow and NO mediated conventional outflow. Bimatoprost grenod can be used for the research of cular hypertension and glaucoma[1][2].
CAS Number
1194396-71-8
Product Name Alternative
NCX 470
UNSPSC
12352005
Hazard Statement
H225-H361
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/bimatoprost-grenod.html
Purity
98.34
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O[C@@H](CCC1=CC=CC=C1)/C=C/[C@@H]2[C@@H](C/C=C\CCCC(NCC)=O)[C@@H](O)C[C@H]2O)CCCCCO[N+]([O-])=O
Molecular Formula
C31H46N2O8
Molecular Weight
574.71
Precautions
P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P405-P501
References & Citations
[1]Impagnatiello F, et al. Prostaglandin analogues and nitric oxide contribution in the treatment of ocular hypertension and glaucoma. Br J Pharmacol. 2019 Apr;176 (8) :1079-1089.|[2]Impagnatiello F, et al. Intraocular Pressure-Lowering Activity of NCX 470, a Novel Nitric Oxide-Donating Bimatoprost in Preclinical Models. Invest Ophthalmol Vis Sci. 2015 Oct;56 (11) :6558-64.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 3

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