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Bimatoprost

CAT: 0804-HY-B0191-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0191-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bimatoprost is a prostaglandin analog that reduces intraocular pressure by regulating scleral and trabecular outflow. Bimatoprost is used in the study of open-angle glaucoma, ocular hypertension, and other forms of glaucoma. Topical application of bimatoprost induces fat atrophy and causes a deepening of the eyelid sulcus[1][2][3][4][5][6].
CAS Number
155206-00-1
Product Name Alternative
AGN 192024
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MMP; Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Field of Research
Endocrinology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Bimatoprost.html
Purity
99.94
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(NCC)CCC/C=C\C[C@@H]1[C@@H](/C=C/[C@@H](O)CCC2=CC=CC=C2)[C@H](O)C[C@@H]1O
Molecular Formula
C25H37NO4
Molecular Weight
415.57
Precautions
H302, H315, H319, H335
References & Citations
[1]Park J, et al. Changes to upper eyelid orbital fat from use of topical bimatoprost, travoprost, and latanoprost. Jpn J Ophthalmol. 2011 Jan;55 (1) :22-7.|[2]Filippopoulos T, et al. Periorbital changes associated with topical bimatoprost. Ophthal Plast Reconstr Surg. 2008 Jul-Aug;24 (4) :302-7.|[3]Stamer W D, et al. Proposed mechanism of long-term intraocular pressure lowering with the bimatoprost implant[J]. Investigative Ophthalmology & Visual Science, 2023, 64 (3) : 15-15.|[4]Patil A J, et al. Bimatoprost–a review[J]. Expert opinion on pharmacotherapy, 2009, 10 (16) : 2759-2768.|[5]Woodward, et al. "Bimatoprost: a novel antiglaucoma agent." Cardiovascular drug reviews 22.2 (2004) : 103-120.|[6]Crowston, et al. "Effect of bimatoprost on intraocular pressure in prostaglandin FP receptor knockout mice." Investigative ophthalmology & visual science 46.12 (2005) : 4571-4577.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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CatalogName
B2139-10Bimatoprost

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