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Rhapontigenin

CAT: 0804-HY-N2229-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N2229-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Rhapontigenin is a natural analog of resveratrol with anticancer, antioxidant, antifungal and antibacterial activities. Rhapontigenin is amechanism-based, potent and selective cytochrome P450 1A1 inactivator (IC50 = 400 nM) . Rhapontigenin exhibits 400-fold and 23-fold selectivity for P450 1A1 over P450 1A2 and P450 1B1, respectively[1].
CAS Number
500-65-2
UNSPSC
12352005
Target
Bacterial; Cytochrome P450; Fungal
Type
Natural Products
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/rhapontigenin.html
Purity
99.66
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
OC1=CC(/C=C/C2=CC=C(OC)C(O)=C2)=CC(O)=C1
Molecular Formula
C15H14O4
Molecular Weight
258.27
References & Citations
[1]Roupe KA, et al. Preparative enzymatic synthesis and HPLC analysis of rhapontigenin: applications to metabolism, pharmacokinetics and anti-cancer studies.J Pharm Pharm Sci. 2005 Aug 22;8 (3) :374-86.|[2]Yeh YH, et al. Rhapontigenin inhibits TGF-β-mediated epithelial‑mesenchymal transition via the PI3K/AKT/mTOR pathway and is not associated with HIF-1α degradation.Oncol Rep. 2016 May;35 (5) :2887-95.|[3]Park EK, et al. Antithrombotic and antiallergic activities of rhaponticin from Rhei Rhizoma are activated by human intestinal bacteria.Arch Pharm Res. 2002 Aug;25 (4) :528-33.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
CYP1

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