WT-161

CAT: 0026-B2219-5Size: 5 mgDry Ice: NoHazardous: No

CAT#:0026-B2219-5Size:5 mg

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AVAILABILITY: InStock

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

WT-161 is a potent, selective, and bioavailable HDAC6 (histone deacetylase-6) inhibitor (IC₅₀ 0.40 nM). It is selective for HDAC6 over HDAC3 (IC₅₀ = 51.61 nM) and induces α-tubulin acetylation, an HDAC6-dependent process, with minimal effect on global lysine acetylation. WT161 inhibits growth of patient-derived multiple myeloma cell lines with IC₅₀ values ranging from 1.5 to 4.7 μM. WT161 enhances the cytotoxicity of bortezomib (Cat. No. 1846) and carfilzomib (Cat. No. 2385) against patient-derived multiple myeloma cells.

Shipping Conditions

gel pack

Storage Conditions

-20°C

Shelf Life

36 months

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WT-161

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