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Triapine

CAT: 0026-B1174-50Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0026-B1174-50Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
3-AP is a ribonucleotide reductase inhibitor and iron chelator with antitumor activity. At 5 μM it can enhance DU145, U251, and PSN1 tumor cell radiosensitivity in vitro, inhibiting DNA synthesis and repair. It destroys the tyrosine free radical in the R2/p53R2 subunits of ribonucleotide reductase by forming a redox active complex with iron, thus producing reactive oxygen species. In addition, 3-AP has been shown to activate an endoplasmic reticulum stress pathway, leading to the unfolded protein response and apoptosis.
Shipping Conditions
gel pack
Storage Conditions
-20°C
Shelf Life
36 months

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