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LY-2109761

CAT: 0026-9605-5Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0026-9605-5Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LY-2109761 is a highly potent and selective TGFβ receptor type I and type II (TβRI/II) inhibitor with Ki of 38 nM and 300 nM respectively. It has been used to study the role of TGF-β signaling in tumor cell migration and metastasis in pancreatic tumor cell lines where it completely disrupts Smad-2 phosphorylation, an immediate downstream target of the kinase activity. It can also suppress radiation-induced inflammatory cytokine signaling and proangiogenic genes, including ID1, in human primary fibrobalsts.
Shipping Conditions
gel pack
Storage Conditions
-20°C
Shelf Life
36 months

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