PF-4708671

CAT: 0026-9460-10Size: 10 mgDry Ice: NoHazardous: No
CAT#:0026-9460-10Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with a Ki of 20 nM and IC₅₀ of 160 nM. PF-4708671 prevents the S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect upon the PMA-induced phosphorylation of substrates of the highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases.
Shipping Conditions
Gel pack
Storage Conditions
-20°C
Shelf Life
36 months

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