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SCH-529704

CAT: 0026-9438-5Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0026-9438-5Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SCH-529074 is a small molecule activator of mutant p53. It binds specifically to the p53 DBD (DNA binding domain) in a saturable manner with an affinity of 1-2 µM. Binding restores wild type function to many oncogenic mutant forms of p53. SCH-529074 reactivates mutant p53 by acting as a chaperone. In addition to reactivating mutant p53, SCH-529074 binding inhibits ubiquitination of p53 by HDM2.
Shipping Conditions
gel pack
Storage Conditions
-20°C
Shelf Life
36 months

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