SB-525334

CAT: 0026-2880-5Size: 5 mgDry Ice: NoHazardous: No
CAT#:0026-2880-5Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SB-525334 is a potent and selective inhibitor of transforming growth factor-β receptor I (ALK5, TGF-βRI) (IC₅₀ = 14.3 nM); displays 4-fold less potency against ALK4 (IC₅₀ = 58.5 nM) and inactive as an inhibitor of ALK2, ALK3, and ALK6 (IC₅₀ > 10,000 nM). In cell-based assays, SB-525334 (1 µM) blocks TGF-β1-induced phosphorylation and nuclear translocation of Smad2/3 in renal proximal tubule cells and inhibits TGF-β1-induced increases in plasminogen activator inhibitor-1 (PAI-1) and procollagen α1(I) mRNA expression in A498 renal epithelial carcinoma cells.
Shipping Conditions
gel pack
Storage Conditions
-20°C
Shelf Life
36 months

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