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ITD-1

CAT: 0026-2879-50Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0026-2879-50Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ITD-1 is a potent and highly selective TGFβ pathway inhibitor (IC₅₀ = 0.85 µM). ITD-1 promotes cardiomyocyte differentiation specifically via degradation of the TGFβ type II receptor (TGFBR2), effectively clearing the receptor from the cell surface and selectively inhibiting intracellular signaling (IC₅₀ =  0.4–0.8 µM), revealing a role for TGFβ signaling mechanism as a repressor of cardiomyocyte fate. ITD-1 does not induce differentiation of vascular smooth muscle cells or endothelial cells.
Shipping Conditions
gel pack
Storage Conditions
-20°C
Shelf Life
36 months

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