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GSK-J4 (Free base)

CAT: 0026-2762-5Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0026-2762-5Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GSK- J4 is cell-permeable ethyl ester of GSK-J1 (Cat. Nos. 2260 & 2761). Acts as a histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC₅₀ = 9 μM for the inhibition of TNFα release). Rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies.
Shipping Conditions
Gel Pack
Storage Conditions
-20°C
Shelf Life
36 months

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