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NSC 405020

CAT: 0026-2682-5Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0026-2682-5Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NSC-405020 is a membrane type-I matrix metalloproteinase (MT1-MMP) inhibitor that specifically targets the hemopexin (PEX) domain rather than the catalytic domain of MT1-MMP (IC₅₀ >100 μmol/L). It does not inhibit the catalytic activity of MT1-MMP or MMP-2. NSC-405020 directly interacts with and binds to PEX in a vicinity of Met-328, Arg-330, Asp-376, Met-22 and Ser-470 of the druggable pocket in the full-length MT1-MMP structure, which affects the conformation and flexibility of blades I to IV of the β-propeller resulting in the decrease of the PEX-dependent homodimerization of cellular MT1-MMP.
Shipping Conditions
Gel pack
Storage Conditions
-20°C
Shelf Life
36 months

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Alternative Products

CatalogName
4902/10NSC 405020
530357NSC-405020
A13072-25NSC 405020 25mg
A13072-5NSC 405020 5mg
A13072-100NSC 405020 100mg
A13072-50NSC 405020 50mg

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