GPRP (acetate)

• Description:

  GPRP acetate (Gly-Pro-Arg-Pro acetate) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa) [1][2][3].

• Product Name Alternative:

  Gly-Pro-Arg-Pro (acetate) ; Pefa 6003 (acetate)

• UNSPSC:

  12352209

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Integrin

• Type:

  Peptides

• Related Pathways:

  Cytoskeleton

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/GPRP-acetate.html

• Purity:

  98.90

• Solubility:

  H2O : 125 mg/mL

• Smiles:

  CC (O) =O.O=C ([C@H]1N (CCC1) C (CN) =O) N[C@@H] (CCCNC (N) =N) C (N2[C@@H] (CCC2) C (O) =O) =O

• Molecular Formula:

  C20H35N7O7

• Molecular Weight:

  485.53

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Gallistl S, et al. Gly-pro-arg-pro (GPRP) enhances free thrombin. Thromb Res. 1995 Jun 15;78 (6) :547-50.|[2]Hsieh KH, et, al. Fibrin Polymerization. 1. Alkylating peptide inhibitors of fibrin polymerization. J Med Chem. 1981 Mar; 24 (3) : 322-7.|[3]Zhang C, et al. Fibrinogen/AKT/Microfilament Axis Promotes Colitis by Enhancing Vascular Permeability. Cell Mol Gastroenterol Hepatol. 2021;11 (3) :683-696.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• Citation 01:

  Cell Mol Gastroenterol Hepatol. 2021;11 (3) :683-696.|Platelets. 2025 Dec;36 (1) :2517108.|Res Pract Thromb Haemost. 2025 Sep 24.

• CAS Number:

  157009-81-9