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Chk2 Inhibitor

CAT: 0026-1702-1Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0026-1702-1Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A cell-permeable, potent, and ATP-competitive inhibitor of Chk2 (checkpoint kinase 2; IC₅₀ = 15 nM; Ki = 37 nM). Displays ~1,000-fold greater selectivity for Chk2 compared to Cdk1/cyclin B and CK1 (IC₅₀ = 12 µM and 17 µM, respectively) and only weakly affects the activities of a panel of 31 kinases (< 25% inhibition at 10 µM), including Chk1. Shown to rescue both peripheral CD4+ and CD8+ T-cells from γ-irradiation-induced apoptosis with an EC₅₀ of 3 µM and 7.6 µM, respectively.
Shipping Conditions
gel pack
Storage Conditions
-20°C
Shelf Life
12 months

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