BAP1-IN-1

• UNSPSC Description:

  BAP1-IN-1 (Compound 8) is a BRCA1 associated protein 1 (BAP1) catalytic activity inhibitor with an IC50 of 0.1-1 μM[1].

• Target Antigen:

  Deubiquitinase

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/bap1-in-1.html

• Purity:

  99.83

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=[N+](C1=CC2=C(NC(C3=CC=CC=C3)C4C2C=CC4)C=C1)[O-]

• Molecular Weight:

  292.33

• References & Citations:

  [1]Wang L, et al. Epigenetic targeted therapy of stabilized BAP1 in ASXL1 gain-of-function mutated leukemia. Nat Cancer. 2021 May;2(5):515-526.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Clinical Information:

  No Development Reported

• CAS Number:

  353495-21-3