Cyclin D1 (Phospho Ser90) rabbit pAb

• Background:

  Disease:A chromosomal aberration involving CCND1 may be a cause of B-lymphocytic malignancy, particularly mantle-cell lymphoma (MCL) . Translocation t (11;14) (q13; q32) with immunoglobulin gene regions. Activation of CCND1 may be oncogenic by directly altering progression through the cell cycle., disease:A chromosomal aberration involving CCND1 may be a cause of multiple myeloma [MIM:254500]. Translocation t (11;14) (q13; q32) with the IgH locus., disease:A chromosomal aberration involving CCND1 may be a cause of parathyroid adenomas [MIM:168461]. Translocation t (11;11) (q13; p15) with the parathyroid hormone (PTH) enhancer., function:Essential for the control of the cell cycle at the G1/S (start) transition., online information:The Singapore human mutation and polymorphism database, PTM:Following DNA damage it is ubiquitinated by some SCF (SKP1-cullin-F-box) protein ligase complex containing FBXO31. Ubiquitination leads to its degradation and G1 arrest., PTM:Phosphorylation at Thr-286 by MAP kinases is required for ubiquitination and degradation following DNA damage. It probably plays an essential role for recognition by the FBXO31 component of SCF (SKP1-cullin-F-box) protein ligase complex., similarity:Belongs to the cyclin family., similarity:Belongs to the cyclin family. Cyclin D subfamily., subunit:Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.

• Description:

  Disease: A chromosomal aberration involving CCND1 may be a cause of B-lymphocytic malignancy, particularly mantle-cell lymphoma (MCL). Translocation t (11;14) (q13;q32) with immunoglobulin gene regions. Activation of CCND1 may be oncogenic by directly altering progression through the cell cycle. Disease: A chromosomal aberration involving CCND1 may be a cause of multiple myeloma [MIM: 254500]. Translocation t (11;14) (q13;q32) with the IgH locus. Disease: A chromosomal aberration involving CCND1 may be a cause of parathyroid adenomas [MIM: 168461]. Translocation t (11;11) (q13;p15) with the parathyroid hormone (PTH) enhancer. function: Essential for the control of the cell cycle at the G1/S (start) transition. online information: The Singapore human mutation and polymorphism database, PTM: Following DNA damage it is ubiquitinated by some SCF (SKP1-cullin-F-box) protein ligase complex containing FBXO31. Ubiquitination leads to its degradation and G1 arrest. PTM: Phosphorylation at Thr-286 by MAP kinases is required for ubiquitination and degradation following DNA damage. It probably plays an essential role for recognition by the FBXO31 component of SCF (SKP1-cullin-F-box) protein ligase complex. similarity: Belongs to the cyclin family. similarity: Belongs to the cyclin family. Cyclin D subfamily. subunit: Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.

• Synonyms:

  G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein;BCL-1;BCL-1 oncogene;PRAD1 oncogene)

• Gene ID:

  595

• UniProt:

  P24385

• Cellular Locus:

  Nucleus. Cytoplasm. Nucleus membrane. Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members..

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse, Rat

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  Synthesized peptide derived from human Cyclin D1 (Phospho Ser90)

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Source:

  Rabbit

• Applications:

  WB, ELISA

• Validated Applications:

  WB, ELISA

• Stability:

  -20°C/1 year

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:1000-2000 ELISA 1:5000-20000

• Molecular Weight:

  33kD

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Observed Molecular Weight:

  33 kD

• Subcellular Location:

  Nucleus . Cytoplasm . Nucleus membrane . Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members. .

• Other Product Names:

  G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein; BCL-1; BCL-1 oncogene; PRAD1 oncogene)

• Gene ID (Human):

  595

• SwissProt (Human):

  P24385