Cyclin D1 (Phospho Ser90) rabbit pAb

Cyclin D1 (Phospho Ser90) rabbit pAb

• Description: Disease: A chromosomal aberration involving CCND1 may be a cause of B-lymphocytic malignancy, particularly mantle-cell lymphoma (MCL). Translocation t (11;14) (q13;q32) with immunoglobulin gene regions. Activation of CCND1 may be oncogenic by directly altering progression through the cell cycle. Disease: A chromosomal aberration involving CCND1 may be a cause of multiple myeloma [MIM: 254500]. Translocation t (11;14) (q13;q32) with the IgH locus. Disease: A chromosomal aberration involving CCND1 may be a cause of parathyroid adenomas [MIM: 168461]. Translocation t (11;11) (q13;p15) with the parathyroid hormone (PTH) enhancer. function: Essential for the control of the cell cycle at the G1/S (start) transition. online information: The Singapore human mutation and polymorphism database, PTM: Following DNA damage it is ubiquitinated by some SCF (SKP1-cullin-F-box) protein ligase complex containing FBXO31. Ubiquitination leads to its degradation and G1 arrest. PTM: Phosphorylation at Thr-286 by MAP kinases is required for ubiquitination and degradation following DNA damage. It probably plays an essential role for recognition by the FBXO31 component of SCF (SKP1-cullin-F-box) protein ligase complex. similarity: Belongs to the cyclin family. similarity: Belongs to the cyclin family. Cyclin D subfamily. subunit: Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.
• Synonyms: G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein;BCL-1;BCL-1 oncogene;PRAD1 oncogene)
• Gene ID: 595
• UniProt: P24385
• Cellular Locus: Nucleus. Cytoplasm. Nucleus membrane. Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members..
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthesized peptide derived from human Cyclin D1 (Phospho Ser90)
• Clonality: Polyclonal
• Validated Applications: WB, ELISA
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: WB 1:1000-2000 ELISA 1:5000-20000
• Molecular Weight: 33kD
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.