E-64-d

• Description:

  E-64-d Catalog number: MDP0689 CAS Number: N/A Sequence: [(2S,3S)-3-Ethoxycarbonyloxirane-2-carbonyl]-L-leucine (3-methylbutyl)amide Amount: 1 mg Molecular Weight: 342.4 g/mol Supplied as: Powder Applications: molecular tool for various biochemical applications Storage: -20 °C WARNING: For in vitro Research Use Only. NOT for use on humans or animals. Grade: Biotechnology grade. All products are highly pure. References: 1: Zhang Z, Huang Z, Dai H, Wei L, Sun S, Gao F. Therapeutic Efficacy of E-64-d, a Selective Calpain Inhibitor, in Experimental Acute Spinal Cord Injury Biomed Res Int. 2015;2015:134242. 2: Ray SK, Matzelle DC, Wilford GG, Hogan EL, Banik NL. E-64-d prevents both calpain upregulation and apoptosis in the lesion and penumbra following spinal cord injury in rats Brain Res. 2000 Jun 9;867(1-2):80-9. 3: Morimoto M, Tanabe F, Kasai H, Ito M. Effect of a thiol proteinase inhibitor, E-64-d, on susceptibility to infection with Staphylococcus aureus in Chediak-Higashi syndrome (beige) mice Int Immunopharmacol. 2007 Jul;7(7):973-80. 4: Yoshifuji H, Umehara H, Maruyama H, Itoh M, Tanaka M, Kawabata D, Fujii T, Mimori T. Amelioration of experimental arthritis by a calpain-inhibitory compound: regulation of cytokine production by E-64-d in vivo and in vitro Int Immunol. 2005 Oct;17(10):1327-36. 5: Tanabe F, Kasai H, He L, Kin T, Fujikado T, Kumamoto T, Hara T, Iwata T, Ito M. Improvement of deficient natural killer activity and delayed bactericidal activity by a thiol proteinase inhibitor, E-64-d, in leukocytes from Chediak-Higashi syndrome patients in vitro Int Immunopharmacol. 2009 Mar;9(3):366-70. 6: Sekiguchi T, Hosoyama Y, Miyata S. Effects of proteasome inhibitor (lactacystin) and cysteine protease inhibitor (E-64-d) on processes of mitosis in Xenopus embryonic cells Zoolog Sci. 2002 Nov;19(11):1251-5. 7: Tanabe F, Nakajima T, Ito M. The thiol proteinase inhibitor E-64-d ameliorates amyloid-β-induced reduction of sAPPα secretion by reversing ceramide-induced protein kinase C down-regulation in SH-SY5Y neuroblastoma cells Biochem Biophys Res Commun. 2013 Nov 8;441(1):256-61. 8: Cui SH, Tanabe F, Terunuma H, Iwatani Y, Nunoi H, Agematsu K, Komiyama A, Nomura A, Hara T, Onodera T, Iwata T, Ito M. A thiol proteinase inhibitor, E-64-d, corrects the abnormalities in concanavalin A cap formation and the lysosomal enzyme activity in leucocytes from patients with Chediak-Higashi syndrome by reversing the down-regulated protein kinase C activity Clin Exp Immunol. 2001 Aug;125(2):283-90. 9: Ray SK, Matzelle DD, Wilford GG, Hogan EL, Banik NL. Cell death in spinal cord injury (SCI) requires de novo protein synthesis. Calpain inhibitor E-64-d provides neuroprotection in SCI lesion and penumbra Ann N Y Acad Sci. 2001 Jun;939:436-49. 10: Shoji-Kasai Y, Senshu M, Iwashita S, Imahori K. Thiol protease-specific inhibitor E-64 arrests human epidermoid carcinoma A431 cells at mitotic metaphase Proc Natl Acad Sci U S A. 1988 Jan;85(1):146-50.
  Products Related to E-64-d can be found at Peptides

• Short Description:

  Catalog Number: MDP0689 (1 mg)

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height:

  0.5

• Height :

  0.5