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Filaggrin Antibody

CAT: 0013-GTR18573762Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18573762Size:100 µg
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Description
Filaggrin (FLG) aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. [UniProt]
UniProt
P20930
Reactivity
Human
Immunogen
A portion of amino acids 998-1104 from the human protein were used as the immunogen for this Filaggrin antibody.
Clonality
Monoclonal
Clone
FLG1-1
Conjugation
Unconjugated
Purification
Protein G affinity chromatography
Dilution
Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
The stated application concentrations are suggested starting points. Titration of the Filaggrin antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Tested Applications
IHC-P
Host or Source
Mouse
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Mouse IgG2b, kappa

UniProtKB · P20930

Filaggrin

FILA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P20930
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FLG
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q01720, Q5T583, Q9UC71
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Ligand

CalciumMetal-binding

PTM

CitrullinationPhosphoprotein

Domain

Coiled coilRepeat

Molecular function

Developmental protein

Disease

Ichthyosis

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