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Filaggrin Antibody

CAT: 0800-V3331SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V3331SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Filaggrin (FLG) is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple Filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional Filaggrin molecules. Active Filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 0.5-1 µg/mL for 30 min at RT
UniProt
P20930
Host
Mouse
Reactivity
Human
Immunogen
Amino acids 198-288 of human FLG were used as the immunogen for this Filaggrin antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
FLG/1562
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1X PBS, pH 7.4
Reconstitution
Store the Filaggrin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Filaggrin antibody is available for research use only.
Storage Conditions
Store the Filaggrin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the Filaggrin antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
IHC testing of FFPE human skin with Filaggrin antibody (clone FLG/1562) . Required HIER: boil tissue sections in 10mM citrate buffer, pH 6, for 10-20 min.

UniProtKB · P20930

Filaggrin

FILA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P20930
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FLG
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q01720, Q5T583, Q9UC71
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Ligand

CalciumMetal-binding

PTM

CitrullinationPhosphoprotein

Domain

Coiled coilRepeat

Molecular function

Developmental protein

Disease

Ichthyosis

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