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Granzyme B Antibody

CAT: 0013-GTR18573755Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18573755Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Granzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'non-self' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkin's Disease.
UniProt
P10144
Reactivity
Human
Immunogen
A recombinant fragment (amino acids 73-187) from the human protein was used as the immunogen for the Granzyme B antibody.
Clonality
Monoclonal
Clone
GZMB/2403
Conjugation
Unconjugated
Purification
Protein G affinity chromatography
Dilution
ELISA: 1-5ug/ml for coating (order BSA/sodium azide-free format)
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the Granzyme B antibody should be determined by the researcher.
Tested Applications
ELISA
Host or Source
Mouse
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Mouse IgG2b, lambda

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