Beta Catenin Antibody

CAT: 0013-GTR18573181Size: 100 µgDry Ice: NoHazardous: No

1 / 1

CAT#:0013-GTR18573181Size:100 µg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

Beta-Catenin associates with the cytoplasmic portion of E-Cadherin, which is necessary for the function of E-Cadherin as an adhesion molecule. In normal tissues, beta-Catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-Catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immunostaining of beta-Catenin and E-Cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas.

UniProt

P35222

Reactivity

Human, Mouse, Rat

Immunogen

A partial human recombinant protein was used as the immunogen for the Beta Catenin antibody.

Clonality

Monoclonal

Clone

CTNNB1/1507

Conjugation

Unconjugated

Purification

Protein G affinity chromatography

Dilution

Immunohistochemistry (FFPE) : 0.1-0.2ug/ml for 30 min at RT

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Applications Notes

Optimal dilution of the Beta Catenin antibody to be determined by the researcher.

Tested Applications

IHC-P

Host or Source

Mouse

Preservative

1 mg/ml in 1X PBS; rAlbumin free, sodium azide free

Isotype

Mouse IgG1, kappa

UniProtKB · P35222

Catenin beta-1

CTNB1_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P35222
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: CTNNB1
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: A8K1L7, Q8NEW9, Q8NI94, Q9H391

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationGlycoproteinPhosphoproteinS-nitrosylationUbl conjugation

Molecular function

Activator

Biological process

Cell adhesionHost-virus interactionNeurogenesisTranscriptionTranscription regulationWnt signaling pathway

Cellular component

Cell junctionCell membraneCell projectionCytoplasmCytoskeletonMembraneNucleusSynapse

Coding sequence diversity

Chromosomal rearrangement

Disease

Disease variantIntellectual disability

Domain

Repeat

Related Products

Catalog	Name
GTR18793509	Catenin beta Antibody
GTR18793510	Catenin beta Antibody
GTR18299881-01	Beta Catenin monoclonal antibody
GTR18293439	Catenin, beta (p120) Antibody
GTR18293436	Catenin, beta (p120) Antibody
GTR18292717	Beta-Catenin (p120) Antibody
GTR18292678	Catenin, beta (p120) Antibody
GTR18212975-01	Beta-catenin monoclonal antibody
GTR18272964	Beta-Catenin Conjugated Antibody
GTR18292674	Catenin, beta (p120) Antibody

Alternative Products

Catalog	Name
MBS2169924-01	Monoclonal Antibody to Beta Catenin (beta-catenin)
MBS9527332-01	Beta-catenin (ABT-Catenin) Antibody
CAU35181-01	Beta Catenin (β-catenin) Monoclonal Antibody
TRV-002898-01	Monoclonal Antibody to Beta Catenin (β-catenin)
CAU26655-01	Beta Catenin (β-catenin) Polyclonal Antibody
TRV-002696-01	Polyclonal Antibody to Beta Catenin (β-catenin)
MBS2111494-01	Anti-Beta Catenin (beta-catenin) Polyclonal Antibody
053169	β-catenin (Beta Catenin)
144285	Catenin beta, CT (Beta-catenin)
MBS2122745-01	Recombinant Beta Catenin (beta-catenin)