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HPV-16 Antibody

CAT: 0013-GTR18572983Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18572983Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Reacts with a protein of 57kDa, identified as the L1 protein of human papilloma virus type 16 (HPV-16) . It is the major capsid protein of HPV-16. Infection with specific types of HPV has been associated with an increased risk of developing cervical neoplasia. HPV types 6 and 11 have been associated with relatively benign diseases such as genital warts but types 16 and 18 are strongly associated with cervical, vaginal, and vulvar malignancies. The antibody reacts very strongly with formalin-fixed, paraffin-embedded tissues containing HPV-16 or -33; very weak reactions were occasionally observed with biopsy specimens or smears containing HPV-6 or HPV-11. It cross-reacts with HPV37.
UniProt
P03101
Reactivity
Virus
Immunogen
Recombinant major capsid protein L1 from human papilloma virus type 16 was used as the immunogen for the HPV-16 antibody.
Clonality
Monoclonal
Clone
SPM405
Conjugation
Unconjugated
Field of Research
Infectious Disease & Virology; Cancer Biology
Purification
Protein G affinity chromatography
Dilution
Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the HPV-16 antibody should be determined by the researcher.1. Staining of formalin-fixed tissues requires boiling tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min followed by cooling at RT for 20 min.
Tested Applications
IHC-P
Host or Source
Mouse
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Mouse IgG2a, kappa

UniProtKB · P03101

Major capsid protein L1

VL1_HPV16 · Human papillomavirus type 16

View on UniProt ↗
Primary accession
P03101
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
L1
Protein existence
1: Evidence at protein level
Organism
Human papillomavirus type 16
Taxonomy ID
333760
Alternative names
—
EC number
—
Processing
—
Secondary accessions
O00530
Protein keywords

Technical term

3D-structureReference proteome

Cellular component

Capsid proteinHost nucleusT=7 icosahedral capsid proteinVirion

PTM

Disulfide bondUbl conjugation

Biological process

Host-virus interactionViral attachment to host cellViral penetration into host cytoplasmVirus endocytosis by hostVirus entry into host cell

Developmental stage

Late protein

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