Products for Research Use Only
RegisterLogin

SUMO-2 Antibody

CAT: 0013-GTR18572742Size: 7 mLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR18572742Size:7 mL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, 2 and 3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2 and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, 2 and 3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins, which include MDM2, p53, PML and RanGap1. SUMO-2 and 3 contribute to a greater percentage of protein modification than does SUMO-1 and unlike SUMO-1, they can form polymeric chains. In addition, SUMO-3 regulates beta-Amyloid generation and may be critical in the onset or progression of Alzheimer s disease.
UniProt
P61956
Reactivity
Human, Rat
Immunogen
Recombinant human protein was used as the immunogen for the SUMO-2 antibody.
Clonality
Monoclonal
Clone
SUMO2/1199
Conjugation
Unconjugated
Purification
Protein G affinity chromatography
Dilution
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the SUMO-2 antibody should be determined by the researcher.1. Staining of formalin/paraffin tissues requires boiling tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min followed by cooling at RT for 20 min.2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Tested Applications
IHC-P
Host or Source
Mouse
Preservative
Prediluted in 1X PBS, 0.1 mg/ml rAlbumin, 0.05% sodium azide; For IHC use only
Isotype
Mouse IgG1, kappa

Related Products

CatalogName
GTR18292206SUMO-2/3 Antibody
GTR18292841SUMO-2/3 Antibody
GTR18083269-01SUMO-2/3 Antibody
GTR18575495SUMO-2/3 Antibody
GTR18575496SUMO-2/3 Antibody
GTR18075486-01Sumo 2+3 Antibody
GTR18273090Sumo 2+3 Conjugated Antibody
GTR18045193-01SUMO-2 (G93) polyclonal antibody
GTR18078155Sumo Antibody
GTR18075056-01SUMO Antibody

Alternative Products

CatalogName
V7051-100UGSUMO-2 Antibody
V9080-20UGSUMO-2/3 Antibody
49224-01Sumo 2+3 Antibody
MBS9456892-01Sumo 2+3 Conjugated Antibody
BS7068-01SUMO-2 (G93) polyclonal antibody
MBS225464SUMO-2 Antibody with Control Lysate
34-165SUMO-2/3 Antibody [SPM572]
ATGA0547-050Human SUMO 2/3 antibody
BML-PW0510A-0100SUMO-2 (human) polyclonal antibody
33-903SUMO-2 Antibody [S2MT-1]

Popular Products