MUC5AC Antibody

CAT: 0013-GTR18572578Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0013-GTR18572578Size:100 µg

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Description

This mAb recognizes the peptide core of gastric mucin M1 (recently identified as Mucin 5AC) . This mucin is present in primary ovarian mucinous cancer but usually absent in colorectal adenocarcinoma, thus showing an expression pattern opposite to MUC2. Together with a panel of antibodies, anti-MUC5AC may be useful for differential identification of primary mucinous ovarian tumors from colon adenocarcinoma metastatic to the ovary. MUC5AC antibodies may also be useful for identification of intestinal metaplasia as well as in the identification of pancreatic carcinoma and pre-cancerous changes vs. normal pancreas.It has been found that treating the testing sample with Papain or mercaptoethanol will destroy the M1 epitope for the 2-11M1 antibody (Ref. 1; Cancer Research 46.8 (1986) : 3983-3989.)

UniProt

P98088

Reactivity

Human, Mouse

Immunogen

An M1 mucin preparation from the fluid of an ovarian mucinous cyst belonging to an O Le (a-b) patient was used as the immunogen for the MUC5AC antibody.

Clonality

Monoclonal

Clone

2-11M1

Conjugation

Unconjugated

Purification

Protein G affinity chromatography

Dilution

ELISA: 2-4ug/ml for coating (order BSA/sodium azide-free format), Western blot: 1-2ug/ml, Flow cytometry: 0.5-1ug/10^6 cells, Immunofluorescence: 1-2ug/ml

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Applications Notes

Optimal dilution of the MUC5AC antibody should be determined by the researcher.

Tested Applications

ELISA, FACS, IF, WB

Host or Source

Mouse

Preservative

1 mg/ml in 1X PBS; rAlbumin free, sodium azide free

Isotype

Mouse IgG1, kappa

UniProtKB · P98088

Mucin-5AC

MUC5A_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P98088
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: MUC5AC
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: MUC-5AC
EC number: —
Processing: Precursor
Secondary accessions: A0A096LPK4, O60460, O76065, Q13792, Q14425, Q658Q1, Q7M4S5, Q8N4M9, Q8WWQ3, Q8WWQ4, Q8WWQ5

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Ligand

CopperMetal-binding

PTM

Disulfide bondGlycoprotein

Domain

RepeatSignal

Cellular component

Secreted

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