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CD11a Antibody / LFA-1

CAT: 0013-GTR18572542Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18572542Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Recognizes a protein of 180 kDa, identified as CD11a (Leucocyte Workshop IV; Code 1524) . CD11a complex with the beta 2 subunit of the integrin family, CD18, to form the cell surface heterodimer, LFA-1 or CD11a /C18 (aLbL) . LFA-1 is expressed on all leukocytes including lymphocytes, monocytes, and granulocytes. It is involved in leukocyte adhesion to its ligands including intercellular adhesion molecule-1 (ICAM-1 or CD54), ICAM-2 (CD102), ICAM-3 (CD50) and Telencephalin (TLN) and play a role in most immune/inflammatory responses. This mAb potently blocks LFA-1 dependent homotypic cell aggregation.
UniProt
P20701
Reactivity
Human
Immunogen
Human CD11a protein was used as the immunogen for the CD11a antibody.
Clonality
Monoclonal
Clone
DF1524
Conjugation
Unconjugated
Field of Research
Immunology & Inflammation
Purification
Protein G affinity chromatography
Dilution
Flow cytometry: 1-2ug/10^6 cells, Immunofluorescence: 1-2ug/ml, Functional studies (order BSA/sodium azide-free format)
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the CD11a antibody should be determined by the researcher.
Tested Applications
FACS, Functional Studies, IF
Host or Source
Mouse
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Mouse IgG2b, kappa

UniProtKB · P20701

Integrin alpha-L

ITAL_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P20701
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ITGAL
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
O43746, Q45H73, Q96HB1, Q9UBC8
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

CalciumMagnesiumMetal-binding

Biological process

Cell adhesionHost-virus interactionPhagocytosis

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoproteinPhosphoprotein

Molecular function

IntegrinReceptor

Domain

RepeatSignalTransmembraneTransmembrane helix

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