Products for Research Use Only
RegisterLogin

Recombinant Bcl-2 Antibody

CAT: 0013-GTR18571611Size: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR18571611Size:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
This antibody recognizes a protein of 25-26kDa, identified as the bcl-2 lpha oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression ofbcl-2 lpha oncoprotein inhibits the programmed cell death (apoptosis) . In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2 lpha protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative.
UniProt
P10415
Reactivity
Human
Immunogen
Amino acids 41-54 (GAAPAPGIFSSQPG) from the human protein were used as the immunogen for the recombinant Bcl-2 antibody.
Clonality
Recombinant
Clone
BCL2/6426R
Conjugation
Unconjugated
Field of Research
Cell Biology
Purification
Protein A/G affinity
Dilution
Immunohistochemistry (FFPE) : 1-2ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the recombinant Bcl-2 antibody should be determined by the researcher.
Tested Applications
IHC-P
Host or Source
Rabbit
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Rabbit IgG

UniProtKB · P10415

Apoptosis regulator Bcl-2

BCL2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P10415
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
BCL2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
C9JHD5, P10416, Q13842, Q16197
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Biological process

ApoptosisAutophagy

Cellular component

CytoplasmEndoplasmic reticulumMembraneMitochondrionMitochondrion outer membraneNucleus

Disease

Disease variantProto-oncogene

PTM

PhosphoproteinUbl conjugation

Domain

TransmembraneTransmembrane helix

Related Products

CatalogName
GTR18221876BCL2/Bcl-2 Antibody
GTR17703193Bcl-2 Antibody
GTR18572709Bcl-2 Antibody
GTR18571808Bcl-2 Antibody
GTR18571806Bcl-2 Antibody
GTR18571756Bcl-2 Antibody
GTR18569436Bcl-2 Antibody
GTR18292726Bcl-2 Antibody
GTR18292725Bcl-2 Antibody
GTR18292125Bcl-2 Antibody

Alternative Products

CatalogName
V3543SAF-100UGRecombinant Bcl-2 Antibody
bsm-10846RBcl-2 Recombinant Antibody
AN300031PRecombinant Bcl-2 Monoclonal Antibody
RAA00499-01BCL-2 Recombinant Monoclonal Antibody
V3671-100UGRecombinant Bcl-2 Antibody / Rabbit Monoclonal
bsm-52304R-PE-01Bcl-2 Recombinant Antibody, PE Conjugated
bsm-52304R-FITC-01Bcl-2 Recombinant Antibody, FITC Conjugated
bsm-52304R-Cy7-01Bcl-2 Recombinant Antibody, Cy7 Conjugated
bsm-52304R-Cy5-01Bcl-2 Recombinant Antibody, Cy5 Conjugated
HEOPP-0217Recombinant Human Bcl-2

Popular Products