Recombinant Bcl6 Antibody

CAT: 0013-GTR18574394Size: 7 mLDry Ice: NoHazardous: No

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CAT#:0013-GTR18574394Size:7 mL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Antibody to Bcl-6 is helpful in a number of diagnostic settings: First, in the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show Bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. Second, Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, Bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. Third, Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) . The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large (L&H) cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.

UniProt

P41182

Reactivity

Human

Immunogen

Amino acids 256-389 were used as the immunogen for the recombinant Bcl6 antibody.

Clonality

Recombinant

Clone

RBCL6/1718

Conjugation

Unconjugated

Field of Research

Immunology & Inflammation

Purification

Protein G affinity chromatography

Dilution

The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Applications Notes

Optimal dilution of the recombinant Bcl6 antibody should be determined by the researcher.1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Tested Applications

IHC-P

Host or Source

Mouse

Preservative

Prediluted in 1X PBS, 0.1 mg/ml rAlbumin, 0.05% sodium azide; For IHC use only

Isotype

Mouse IgG1, kappa

UniProtKB · P41182

B-cell lymphoma 6 protein

BCL6_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P41182
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: BCL6
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: BCL-6
EC number: —
Processing: —
Secondary accessions: A7E241, B8PSA7, D3DNV5

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoproteinUbl conjugation

Molecular function

ActivatorDNA-bindingRepressor

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Biological process

ImmunityInflammatory responseTranscriptionTranscription regulation

Ligand

Metal-bindingZinc

Cellular component

Nucleus

Disease

Proto-oncogene

Domain

RepeatZinc-finger

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