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YY173

CAT: 0804-HY-163787Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-163787Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
YY173 is a dual inhibitor for CDK4 and CDK6 with IC50 of 7.7 and 88 nM. YY173 inhibits the proliferation of cell Jurkat with an IC50 of 1.46 μM. YY173 can be used for synthesis of PROTAC CDK4/6 degrader 1.
CAS Number
330550-51-1
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/yy173.html
Smiles
O=C1N(C2=NC(NC3=CC=C(C=C3)N4CCNCC4)=NC=C2N=C1)C5CCCC5
Molecular Formula
C21H25N7O
Molecular Weight
391.47
References & Citations
[1]He H, et al., Development of Degraders of Cyclin-Dependent Kinases 4 and 6 Based on Rational Drug Design. J Med Chem. 2024 Jul 11;67 (13) :11354-11364.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK4; CDK6

Alternative Products

CatalogName
GTR19236392-01YY173

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