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PFM01

CAT: 0804-HY-116770-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-116770-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PFM01, N-alkylated Mirin derivative, is a MRE11 endonuclease inhibitor. PFM01 can regulate double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) versus homologous recombination (HR) [1][2].
CAS Number
1558598-41-6
Product Name Alternative
Stibogluconate (trisodium nonahydrate)
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Endonuclease
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pfm01.html
Concentration
10mM
Purity
99.91
Solubility
DMSO : ≥ 100 mg/mL|Ethanol : 25 mg/mL (ultrasonic)
Smiles
O=C1N(CC(C)C)C(S/C1=C\C2=CC=C(O)C=C2)=S
Molecular Formula
C14H15NO2S2
Molecular Weight
293.40
Precautions
H302, H315, H319
References & Citations
[1]Shibata A, et, al. DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol Cell. 2014 Jan 9; 53 (1) : 7-18.|[2]Völkening L, et, al. RAD50 regulates mitotic progression independent of DNA repair functions. FASEB J. 2020 Feb; 34 (2) : 2812-2820.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Pfm01
CAS Number1558598-41-6
PubChem CID2145809
IUPAC Name(5Z)-5-[(4-hydroxyphenyl)methylidene]-3-(2-methylpropyl)-2-sulfanylidene-1,3-thiazolidin-4-one
Molecular FormulaC14H15NO2S2
Molecular Weight293.4
XLogP4
Topological Polar Surface Area97.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count19
Formal Charge0
Complexity398
SMILES
CC(C)CN1C(=O)/C(=C/C2=CC=C(C=C2)O)/SC1=S
InChI
InChI=1S/C14H15NO2S2/c1-9(2)8-15-13(17)12(19-14(15)18)7-10-3-5-11(16)6-4-10/h3-7,9,16H,8H2,1-2H3/b12-7-
InChIKey
GPURHDUTZUYAFI-GHXNOFRVSA-N
Chemical Structure
2D Structure
2D structure of Pfm01
CAS: 1558598-41-6
CID: 2145809
Formula: C14H15NO2S2
MW: 293.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight293.4
XLogP34
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass293.05442107
Monoisotopic Mass293.05442107
Topological Polar Surface Area97.9 Ų
Heavy Atom Count19
Formal Charge0
Complexity398
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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