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2'-Deoxyuridine

CAT: 0804-HY-D0186-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-D0186-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
2’-deoxyuridine is a brain-penetrant pyrimidines nucleotide that is associated with nervous system diseases. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. 2'-Deoxyuridine is a precursor in the synthesis of Edoxudine and also an analogue of 5-ethynyl-2'-deoxyuridine, EdU (HY-118411). 2’-deoxyuridine reduces microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury, which is promising for research of Alzheimer’s disease (AD)[2][3].
CAS Number
951-78-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite; Thymidylate Synthase
Type
Natural Products
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/2_acute_-Deoxyuridine.html
Purity
99.98
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(N1)N([C@H]2C[C@H](O)[C@@H](CO)O2)C=CC1=O
Molecular Formula
C9H12N2O5
Molecular Weight
228.20
Precautions
H302, H315, H319, H335
References & Citations
[1]Reidy JA, et al. Deoxyuridine increases folate-sensitive fragile site expression in human lymphocytes. Am J Med Genet. 1987 Jan;26 (1) :1-5.|[2]Ashraf Saad Rasheed, et al. Development of ZIC-HILIC methods using ultraviolet detection for determining 2-deoxyuridine in human serum[J]. Systematic Reviews in Pharmacy. 2020 March; 11 (2) :388-394.|[3]Liu M, et al. Thymidine and 2'-deoxyuridine reduce microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury[J]. Arch Biochem Biophys. 2022 Oct 30;729:109377.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite; Microbial Metabolite

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