2'-Deoxyuridine

• UNSPSC Description:

  2’-deoxyuridine is a brain-penetrant pyrimidines nucleotide that is associated with nervous system diseases. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. 2'-Deoxyuridine is a precursor in the synthesis of Edoxudine (HY-B1011) and also an analogue of 5-ethynyl-2'-deoxyuridine, EdU (HY-118411). 2’-deoxyuridine reduces microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury, which is promising for research of Alzheimer’s disease (AD)[1][2][3].

• Target Antigen:

  Endogenous Metabolite; Thymidylate Synthase

• Type:

  Natural Products

• Related Pathways:

  Apoptosis;Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/2_acute_-Deoxyuridine.html

• Purity:

  99.98

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(N1)N([C@H]2C[C@H](O)[C@@H](CO)O2)C=CC1=O

• Molecular Weight:

  228.204

• References & Citations:

  [1]Reidy JA, et al. Deoxyuridine increases folate-sensitive fragile site expression in human lymphocytes. Am J Med Genet. 1987 Jan;26(1):1-5.|[2]Ashraf Saad Rasheed, et al. Development of ZIC-HILIC methods using ultraviolet detection for determining 2-deoxyuridine in human serum[J]. Systematic Reviews in Pharmacy. 2020 March; 11(2):388-394.|[3]Liu M, et al. Thymidine and 2'-deoxyuridine reduce microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury[J]. Arch Biochem Biophys. 2022 Oct 30;729:109377.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  951-78-0