JAK-IN-37

• UNSPSC Description:

  JAK-IN-37 (Compound WU4) is a JAK inhibitor, with IC50 values of 0.52, 2.26, 84 and 1.09 nM for JAK1, JAK2, JAK3 and JAK4, respectively. JAK-IN-37 can be used for the research of allogeneic hematopoietic cell transplantation (allo-HCT)[1].

• Target Antigen:

  JAK

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/jak-in-37.html

• Smiles:

  O=S(NC(C1)CC1(C2)CC2(CC#N)N3N=CC(C4=C5C(NC=C5)=NC=N4)=C3)(CC)=O

• Molecular Weight:

  425.51

• References & Citations:

  [1]Kim S, et al. Novel JAK Inhibitors to Reduce Graft-Versus-Host Disease after Allogeneic Hematopoietic Cell Transplantation in a Preclinical Mouse Model. Molecules. 2024 Apr 16;29(8):1801.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported