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VU0448088

CAT: 0804-HY-162663-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-162663-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VU0448088 (ML253) is a potent and cross the blood-brain barrier tricyclic muscarinic acetylcholine receptor subtype 4 (M4) positive allosteric modulator with EC50 values of 56, 176 nM for human and rat, respectively. VU0448088 has the potential for the research of psychotic[1][2].
CAS Number
1417616-42-2
Product Name Alternative
ML253
UNSPSC
12352211
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vu0448088.html
Purity
98.67
Solubility
DMSO : 5 mg/mL (ultrasonic)
Smiles
CC1=C(Cl)C(C)=NC2=C1C(N)=C(C(NCC3=CC=NC=C3)=O)S2
Molecular Formula
C16H15ClN4OS
Molecular Weight
346.83
References & Citations
[1]Le U, et al. Discovery of a selective M₄ positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia. Bioorg Med Chem Lett. 2013 Jan 1;23 (1) :346-50.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAChR4

Alternative Products

CatalogName
GTR19236328-01VU0448088

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